| Autor: |
Rapisa Nantanee, Peera Jaru-Ampornpan, Napaporn Chantasrisawad, Orawan Himananto, Supawan Papakhee, Jiratchaya Sophonphan, Monta Tawan, Thidarat Jupimai, Suvaporn Anugulruengkitt, Thanyawee Puthanakit |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Vaccine: X, Vol 15, Iss , Pp 100367- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1362 |
| DOI: |
10.1016/j.jvacx.2023.100367 |
| Popis: |
Background: Children 6 months to 6 months(N = 40) prior to vaccination. Participants in Group A and B received 2-dose BNT162b2 intramuscularly 1 month apart. COVID-naïve children were enrolled as a control group (N = 40) and received 3-dose BNT162b2 at month 0,1,3. Neutralizing antibody against Omicron variant(BA.2.75 and BA.4/5) was determined by pseudovirus assays(pVNT) as reported by neutralization dilution for 50%inhibition (ID50) at 28 days after the 1st and 2nd dose. Results: From October-November 2022, 120 children with a median age of 2.8 years (IQR 1.6–4.0) were enrolled. The median duration since COVID-19 to vaccination was 4.4 months(IQR 3.8–5.4) in Group A and 7.9 months(7.0–8.5) in Group B. In Group A, the geometric means(GMs) of pVNT-BA.2.75 ID50 were 553 (95%CI 338–906) and 753(516–1098) after 1 and 2 doses, respectively, and the GMs of pVNT-BA.4/5 ID50 were 1936(1402–2673) and 1885(1414–2512), respectively. In Group B, the GMs of pVNT-BA.2.75 ID50 were 1383(1100–1742) and 1419 (1104–1823), and the GMs of pVNT-BA.4/5 ID50 were 2627(2048–3367) and 2056(1546–2735), respectively. Meanwhile in COVID-naïve group, the GMs of pVNT-BA.2.75 and pVNT-BA.4/5 ID50 were 158(98–255) and 59(31–114) after the 3rd dose, respectively. The geometric mean ratio(GMR) of pVNT-BA.2.75 ID50 after 1 dose in Group A and B compared with after 3 doses in COVID-naïve group were 3.50 (1.93–6.34) and 8.74 (4.79–15.95), respectively. The GMR of pVNT-BA.2.75 ID50 after 1 dose in Group B compared with Group A was 2.50 (1.45–4.31). Conclusions: Children previously infected with SARS-CoV-2 Omicron variant, developed robust neutralizing antibody response against Omicron variant after single-dose BNT162b2. Children with an interval of > 6 months since COVID-19 infection developed higher neutralizing antibody response compared to those with a 3-to-6-month interval. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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