Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis

Autor: Sharon Kuzi, Dana Adlersberg, Itamar Aroch, Gilad Segev
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 37, Iss 2, Pp 437-445 (2023)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16638
Popis: Abstract Background The utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐(DGGR)‐lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. Objective To examine the association of DLA with clinical signs of CP, as assessed by a CP clinical severity score (CPCSS). Animals: Twenty‐four dogs. Methods This is a retrospective study. Chronic pancreatitis was diagnosed based on clinical signs and DLA > 250 U/L and monitored using CPCSS and DLA. Results The study included 134 visits (median, 10 visits/dog; range, 2‐11). Mild‐moderate (CPCSS, 0‐3) and severe (CPCSS, ≥4) disease were documented in 94 (70%) and 40 (30%) visits, respectively. In emergency visits (n = 44; 33%) CPCSS (median, 5; range, 0‐15) and DLA (median, 534 U/L; range, 63‐7133) were higher (P
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