Human Prostatic Acid Phosphatase: Structure, Function and Regulation

Autor: William G. Chaney, Sakthivel Muniyan, Nagendra K. Chaturvedi, Chad A. LaGrange, Jennifer G. Dwyer, Ming-Fong Lin
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 10438-10464 (2013)
Druh dokumentu: article
ISSN: 1422-0067
DOI: 10.3390/ijms140510438
Popis: Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.
Databáze: Directory of Open Access Journals