Association between interleukin-6 levels and stroke: a systematic review and meta-analysis
| Autor: | Xinyi Huang, Manman Zhang, Jiaojiao Wang, Fuyong Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of International Medical Research, Vol 52 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1473-2300 03000605 |
| DOI: | 10.1177/03000605241274626 |
| Popis: | Objectives We aimed to evaluate the association of interleukin-6 (IL-6) expression levels with stroke. Methods According to the set search strategy, we systematically screened relevant studies using PubMed and extracted study results regarding IL-6 from the literature for comprehensive quantitative analysis to explore the relationship between IL-6 level and stroke risk. Results This study included 15 publications with a total of 1696 participants, with 975 cases in the case group and 721 cases in the control group. Meta-analysis showed that IL-6 levels were significantly higher in the stroke population than those in the control group (standardized mean difference = 1.22, 95% confidence interval = 0.79–1.64). Subgroup analysis showed that there was no significant difference in heterogeneity for IL-6 detection methods between the two groups ( I 2 = 0, P = 0.47). The difference in heterogeneity test results regarding geographic region was statistically significant ( I 2 = 89.7%, P |
| Databáze: | Directory of Open Access Journals |
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