Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression

Autor:	Shujun Zhang, Yafeng Liu, Xiao Ma, Xiaohui Gao, Yi Ru, Xinjun Hu, Xinyu Gu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	N-acetyltransferase 10 N4-acetylcytidine Tumor mRNA Medicine Cytology QH573-671
Zdroj:	Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	1478-811X
DOI:	10.1186/s12964-023-01417-5
Popis:	Abstract N4-acetylcytidine (ac4C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is significantly associated with various human diseases, especially cancer, and its formation depends on the catalytic activity of N-acetyltransferase 10 (NAT10), the only known protein that produces ac4C. This review discusses the detection techniques and regulatory mechanisms of ac4C and summarizes ac4C correlation with tumor occurrence, development, prognosis, and drug therapy. It also comments on a new biomarker for early tumor diagnosis and prognosis prediction and a new target for tumor therapy. Video Abstract
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7732465550ee4a6abc25e5e4bedf53b2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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