| Autor: |
Tyerman Jabus G, Ponciano José M, Joyce Paul, Forney Larry J, Harmon Luke J |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
BMC Evolutionary Biology, Vol 13, Iss 1, p 22 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2148 |
| DOI: |
10.1186/1471-2148-13-22 |
| Popis: |
Abstract Background Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes. Results Using Escherichia coli biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic selection. Conclusions Our results demonstrate the rapid de novo evolution of heritable variation in antibiotic sensitivity and resistance during E. coli biofilm development. We suggest that evolutionary processes, whether genetic drift or natural selection, should be considered as a factor to explain the elevated tolerance to antibiotics typically observed in bacterial biofilms. This could be an under-appreciated mechanism that accounts why biofilm populations are, in general, highly resistant to antibiotic treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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