Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

Autor:	Melania Lo Iacono, Chiara Modica, Gaetana Porcelli, Ornella Roberta Brancato, Giampaolo Muratore, Paola Bianca, Miriam Gaggianesi, Alice Turdo, Veronica Veschi, Matilde Todaro, Simone Di Franco, Giorgio Stassi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	tumor microenvironment adipose tissue cancer stem cells adipokines exosomes target therapy Microbiology QR1-502
Zdroj:	Biomolecules, Vol 12, Iss 5, p 702 (2022)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom12050702
Popis:	The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
Databáze:	Directory of Open Access Journals
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