| Autor: |
Suraj N. Mali, Anima Pandey, Bapu Thorat |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
SynOpen, Vol 07, Iss 01, Pp 102-109 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2509-9396 |
| DOI: |
10.1055/a-2035-6493 |
| Popis: |
A simple, eco-friendly and straightforward synthesis of hydrazones has been devised that is conducted in the presence of chitosan Hydrochloride (chitosan·HCl) as catalyst in aqueous-ethanol medium at room temperature. The current protocol offers metal-free synthesis, adaptability to large-scaleup, good yields, and quicker reaction time. All ten synthesized hydrazones also showed good antimycobacterial activity, with minimum inhibitory concentrations (MICs) ranging from 3.12 to 6.25 μg/mL. One of the products presented strong binding affinity against M. tuberculosis pantothenate synthetase (pdb id: 3IVX) with a Glide docking score of –8.803 kcal/mol. Molecular dynamics simulation analysis of its complex with 3IVX retained good stability over the simulation period of 20 ns. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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