| Autor: |
Monira Sarmin, Fhameda Akter, Anika Nawrin Islam, Mustafa Mahfuz, Subhasish Das, Sharifuzzaman, S.M. Tafsir Hasan, Taufiqur Rahman Bhuiyan, Mustafizur Rahman, Amran Gazi, Fariha Bushra Matin, Md Tariqujjaman, Lubaba Shahrin, Mofakharul Islam, Asif Mujtaba Mahmud, Sayera Banu, Mohammod Jobayer Chisti, Firdausi Qadri, John David Clemens, Tahmeed Ahmed |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 10, Iss 23, Pp e40532- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2024.e40532 |
| Popis: |
Objective: In COVID-19, cytokine storms (CS) result in higher mortality and morbidity. Our study evaluated the rate of cytokine storms among COVID-positive Bangladeshi adults. Methods: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults. COVID-positive cases were treated in a makeshift COVID unit of icdr,b Dhaka Hospital. CS was defined as having IL-6 >80 pg/mL or any three of the following: high CRP, ferritin, LDH, D-dimer, or low lymphocyte. Stored plasma samples were tested for the cytokines IL-6, IL-1β, and TNF-α. Results: This study involved 77 participants, 32 were in the severe-critical group, 30 were in the mild-moderate group, and 14 were COVID-negative. Twelve participants in the severe-critical group had CS. Thus, the rate of CS was 37.5 % (12/32). Compared to COVID-19-negative patients, COVID-19-positive patients had higher IL-6 levels, which decreased at discharge except for those dying. Among the COVID-19-positive patients, nine died. For both the mild-moderate and severe-critical patients, IL-6 increased with increasing CRP (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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