DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

Autor: Danni A. Gadd, Hannah M. Smith, Donncha Mullin, Ola Chybowska, Robert F. Hillary, Dorien M. Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Rosie M. Walker, Kathryn L. Evans, Andrew M. McIntosh, Caroline Hayward, Tom C. Russ, Sarah E. Harris, Paul Welsh, Naveed Sattar, Simon R. Cox, Daniel L. McCartney, Riccardo E. Marioni
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Druh dokumentu: article
ISSN: 1868-7083
DOI: 10.1186/s13148-024-01734-7
Popis: Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proBNP may provide new routes for risk stratification. Results In the Generation Scotland cohort (N ≥ 16,963), GDF15 levels were associated with incident dementia, ischaemic stroke and type 2 diabetes, whereas NT-proBNP levels were associated with incident ischaemic heart disease, ischaemic stroke and type 2 diabetes (all PFDR 95%) with levels of GDF15 and NT-proBNP, respectively. EpiScores for GDF15 and NT-proBNP were trained in a subset of the population. The GDF15 EpiScore replicated protein associations with incident dementia, type 2 diabetes and ischaemic stroke in the Generation Scotland test set (hazard ratios (HR) range 1.36–1.41, PFDR
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