| Autor: |
Christoph Arolt, Andreas H. Scheel, Margaret Dugan, Robert Wild, Vanessa Richartz, Barbara Holz, Johannes Brägelmann, Svenja Wagener-Ryczek, Sabine Merkelbach-Bruse, Juergen Wolf, Reinhard Buettner, Luigi Catanzariti, Matthias Scheffler, Axel M. Hillmer |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2397-768X |
| DOI: |
10.1038/s41698-024-00744-1 |
| Popis: |
Abstract Our recently published K1N2-score robustly predicts KEAP1/NFE2L2-mutations and pathway activation status, while its accessibility might be limited. We tested if the RNA expression data of six pathway-related genes and NQO1-IHC might be a reliable alternative using 348 KEAP1/NFE2L2 mutation-enriched NSCLC. While TXNRD1 RNA testing was the best-performing single-gene test, the combination of single-gene screening and validation with the K1N2-score achieved the highest performance when predicting mutation status or pathway activation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink