Early evidence on genetic polymorphisms in conferring a 'Two-Hit' propensity to renal injury in Asian Indian children

Autor:	Suramya Anand, Minu Bajpai, Alok Kumar, Siddharth Kapahtia
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	angiotensin ii receptor type 2 gene congenital anomalies of the kidney and urinary tract nephrogenic genes Pediatrics RJ1-570 Surgery RD1-811
Zdroj:	Journal of Indian Association of Pediatric Surgeons, Vol 27, Iss 6, Pp 741-746 (2022)
Druh dokumentu:	article
ISSN:	0971-9261 1998-3891
DOI:	10.4103/jiaps.jiaps_84_22
Popis:	Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of end-stage renal disease in children. While certain nephrogenic genes have been incriminated in these malformations, data to identify the frequency of gene polymorphisms in Asian Indian children with CAKUT are scarce. This study was done to identify the effect of polymorphisms in paired-box gene 2 (PAX2), bone morphogenetic protein (BMP)-4, angiotensin-converting enzyme (ACE), and angiotensin II receptor Type 2 (AGTR2) nephrogenic genes on the development of CAKUT. Materials and Methods: In this prospective cohort study, 158 children
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/76db6dba4a5c4abf9ba022ba649f237c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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