| Autor: |
Azza Farag Said, Bahaa Ibrahim Mohamed, Esmat El-Sharkawy, Miral Al-Sherif |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Egyptian Journal of Chest Disease and Tuberculosis, Vol 62, Iss 3, Pp 419-424 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
0422-7638 |
| DOI: |
10.1016/j.ejcdt.2013.07.016 |
| Popis: |
Background: Conventional TB diagnosis continues to rely on smear microscopy, culture and chest radiography. Other non-conventional approaches include detection of immunological response and the search for biochemical markers. Cancer antigen 125 (Ca-125) was evaluated mainly in patients with extra pulmonary TB. Objective: This study was designed to detect the role of Ca-125 in differentiating pulmonary tuberculosis from other pulmonary infections. Also to determine the value of Ca-125 was an indicator of response to anti-tuberculous drugs. Design: Eighty patients were included in the study, 27 with active pulmonary TB and 33 with other pulmonary infections. Twenty healthy volunteers were used as a control group. Measurement of serum Ca-125 was performed once in all groups, it was re-assayed after 4 months of anti-tuberculous drugs among patients with active pulmonary TB. Results: There was a significant increase of Ca-125 among patients with active pulmonary TB than the other groups, which decrease significantly after anti-tuberculous drugs. The sensitivity and specificity of Ca-125 were found to be 81.4% and 95%, respectively, at a 34.6 U/ml cut-off point. Conclusion: Ca-125 can be a useful marker in differentiating pulmonary TB from other pulmonary infections and in assessment the response to anti-tuberculoussis drugs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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