| Autor: |
Dmitry V. Osipov, Kirill S. Korzhenko, Vitaly A. Osyanin |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Reactions, Vol 3, Iss 4, Pp 625-633 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2624-781X |
| DOI: |
10.3390/reactions3040042 |
| Popis: |
A new three-component condensation of β-ketonitriles, 4-fluorobenzaldehyde, and secondary cyclic amines was developed. A possible reaction mechanism has been proposed including Knoevenagel condensation followed by aromatic nucleophilic substitution. It was found that in the case of 3-oxopropanenitrile bearing the 6-amino-1,3-dimethyluracil moiety, the reaction is not accompanied by fluorine substitution in the Knoevenagel adduct, and the Michael addition of a secondary amine occurs followed by oxidation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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