Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature
| Autor: | Vijay Gayam MD, Mazin Khalid MD, Binav Shrestha MD, Muhammad Rajib Hossain MD, Sumit Dahal MD, Pavani Garlapati MD, Arshpal Gill BHsc, Amrendra Kumar Mandal MD, Ruby Sangha BSc |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Investigative Medicine High Impact Case Reports, Vol 6 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2324-7096 23247096 |
| DOI: | 10.1177/2324709618761754 |
| Popis: | Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrates the importance of valproic acid, fluconazole, and amiodarone as potential hepatoxic agents of drug-induced liver injury leading to acute hepatic failure. The causality in all cases was established by Roussel Uclaf Causality Assessment Method/Council for International Organizations of Medical Sciences score and Naranjo Algorithm. Obesity, hypo-perfusion state, and concurrent hepatotoxic agent might identify at-risk patients. Further studies are required to understand the risk factors. |
| Databáze: | Directory of Open Access Journals |
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