C3c沉积可预测2型糖尿病患者经活检证实的糖尿病肾病更差的肾脏结局

Autor: Meng‐Rui Li, Zi‐Jun Sun, Dong‐Yuan Chang, Xiao‐Juan Yu, Su‐Xia Wang, Min Chen, Ming‐Hui Zhao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Diabetes, Vol 14, Iss 4, Pp 291-297 (2022)
Druh dokumentu: article
ISSN: 1753-0407
1753-0393
DOI: 10.1111/1753-0407.13264
Popis: Abstract Background Although extensive efforts have been paid to identify reliable predictors for renal outcomes of diabetic kidney disease (DKD) patients in type 2 diabetes mellitus (T2DM), there are still only a limited number of predictive factors for DKD progression. Increasing evidence reported the role of the overactivated complement system in the pathogenesis of DKD. Whether renal complement depositions are associated with renal outcomes of DKD in T2DM is of interest. Methods A total of 213 biopsy‐proven DKD patients with T2DM were retrospectively recruited. Clinical and pathological data of the patients were analyzed. Kaplan‐Meier analysis and Cox regression analysis were performed to explore predictors of end‐stage renal disease (ESRD). Results During a median follow‐up of 23.0 (12.0, 39.0) months, 100/213 (46.9%) patients progressed to ESRD. C3c and C1q deposition were observed in 133/213 (62.4%) and 45/213 (21.1%) patients, respectively. Kaplan‐Meier analysis revealed patients with C3c or C1q deposition had significantly worse renal outcomes compared with those without C3c or C1q deposition (p = .001 and p
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