| Autor: |
Masahiro Katsurada, Motoko Tachihara, Naoko Katsurada, Naoya Takata, Hiroki Sato, Chihiro Mimura, Junya Yoshioka, Koichi Furukawa, Masako Yumura, Takehiro Otoshi, Yuichiro Yasuda, Tatsunori Kiriu, Daisuke Hazama, Tatsuya Nagano, Masatsugu Yamamoto, Yoshihiro Nishimura, Kazuyuki Kobayashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2407 |
| DOI: |
10.1186/s12885-022-09640-y |
| Popis: |
Abstract Background Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of the combination of midazolam and pethidine during bronchoscopy. Methods In this prospective randomized single (patient)-blind study, we randomly assigned 100 patients who were scheduled to undergo bronchoscopy biopsy to receive treatment with either the midazolam/pethidine combination (combination group) or midazolam alone (midazolam group) during examinations. After the end of bronchoscopy, patients completed a questionnaire and the visual analogue scale was measured. The primary outcome was the patients’ acceptance of re-examination assessed by visual analogue scale. We also assessed pain levels, vital signs, midazolam use, xylocaine use, and adverse events. Univariate analyses were performed using Fisher’s exact test for categorical data, and the t-test or Mann-Whitney test was carried out for analysis of numeric data. All P-values were two-sided, and values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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