Effects of hydrochlorothiazide on kidney stone therapy with extracorporeal shock wave lithotripsy

Autor: Ali Tehranchi, Yousef Rezaei, Mohammadreza Mohammadi-Fallah, Mohammadreza Mokhtari, Mansour Alizadeh, Farzad Abedi, Masoud Khalilzadeh, Parisa Tehranchi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Urology Annals, Vol 6, Iss 3, Pp 208-211 (2014)
Druh dokumentu: article
ISSN: 0974-7796
0974-7834
DOI: 10.4103/0974-7796.134261
Popis: Objective: The aim of this investigation was to assess the efficacy of hydrochlorothiazide as a hypocalciuric diuretic on stone-free rate of renal pelvic calculi after extracorporeal shock wave lithotripsy (ESWL). Materials and Methods: A double-blind, placebo-controlled randomized clinical trial was conducted and 52 patients with renal pelvic calculi (diameter ≤2 cm) were enrolled from February 2010 to September 2010. ESWL protocol was performed by 2,500 shocks per session. The patients were randomized into two groups: (1) 26 patients who were given 25 mg hydrochlorothiazide twice daily; and (2) 26 patients who received placebo. The stone-free rate was defined as residual calculus size ≤4 mm in controlled ultrasound on 2 nd week, 1 month and 3 months after ESWL. Results: 19 (78%) of the first group and 9 (42.9%) of the second group were stone-free after one session of ESWL (P = 0.02). 88% of the group 1 and 47.8% of the group 2 were stone-free on 1 month after ESWL (P = 0.003); however, this effect of hydrochlorothiazide was not related to the patients′ body mass index, age and gender. The accessory treatment procedures were applied in 24% of the group 1 compared with 19% of the group 2 during 3 months (P = 0.68). All patients in both groups were stone-free on 3 months following lithotripsy. Conclusions: Hydrochlorothiazide did not impact on the stone-free rate and using accessory procedure within 3 months; however, it decreased duration of stone-free status and number of ESWL sessions.
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