Chronotype, chrononutrition and glucose tolerance among prediabetic individuals: research protocol for a prospective longitudinal study Chrono-DM™

Autor: Guey Yong Chong, Satvinder Kaur, Ruzita Abd Talib, See Ling Loy, Hui Yin Tan, Sarjit Singh Harjit Singh, Rosmiza Binti Abdullah, Hanisah Binti Mahmud, Woan Yie Siah, Hui Chin Koo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Primary Care, Vol 23, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2731-4553
DOI: 10.1186/s12875-022-01815-7
Popis: Abstract Background Chronotype and chrononutrition, both are emerging research interests in nutritional epidemiology. However, its association with glycemic control in the Asia population is less clear. A better understanding of how activity/eating time can influence glucose levels in Asian prediabetic individuals may improve strategies for blood glucose control in Asian countries. The present paper describes the research protocol which aims to determine the associations of chronotype and chrononutrition with glucose tolerance among Malaysian prediabetic individuals. Methods This is a prospective longitudinal study named Chrono-DM™, that targets to recruit 166 newly diagnosed prediabetic individuals from the community clinics in Malacca, Malaysia. Respondents will be followed-up for 6 months: (1) baseline (1st oral glucose tolerance test (OGTT)); (2) second visit (at 3rd month); and (3) third visit (2nd OGTT at 6th month). Data collection includes sociodemographic and anthropometry measurements (weight, height, body fat, visceral fat, waist and hip circumference). Dietary intake and meal timing are collected using the 3-day dietary record while data on sleep pattern, light exposure, chronotype and chrononutrition will be collected using validated questionnaires. Physical activity will be recorded using a validated IPAQ questionnaire and pedometer during periods of using continuous glucose monitoring (CGM) sensor. CGM, fasting blood sugar (FBS), OGTT and HbA1c are performed to assess glycemic outcomes. Discussion The Chrono-DM™ study represents a novel approach to determining the association of chronotype and chrononutrition with glycemic control. We anticipate that this study will not only review the association of chronotype with glycemia measure but also provide greater insight into optimal meal time for glycemic control among prediabetic individuals in the Asian population. Trial registration NCT05163964 (Clinicaltrial.gov). Trial registration date: 20 December 2021.
Databáze: Directory of Open Access Journals
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