Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone
| Autor: | Leila Hosseinzadeh, Alireza Aliabadi, Masoud Kalantari, Abolfazl Mostafavi, Marzieh Rahmani Khajouei |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Research in Pharmaceutical Sciences, Vol 11, Iss 3, Pp 210-218 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1735-5362 1735-9414 |
| Popis: | Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line. |
| Databáze: | Directory of Open Access Journals |
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