Adhesion molecules: a way to understand lupus

Autor:	Karolina Nowak, Olga Gumkowska-Sroka, Przemysław Kotyla
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	systemic lupus erythematosus endothelial dysfunction endothelial biomarkers cell adhesion molecules. Medicine
Zdroj:	Rheumatology, Vol 60, Iss 2, Pp 133-141 (2022)
Druh dokumentu:	article
ISSN:	0034-6233 2084-9834
DOI:	10.5114/reum.2022.115664
Popis:	Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of the disease. Among them, endothelial damage and dysfunction seem to play a pivotal role. Endothelial damage can be accurately measured using adhesion molecules such asintercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), platelet endothelial cell adhesion molecule (PECAM) and selectins. In this review we discuss the role of well-known cellular adhesion molecules as pathogenic factors in disease development as well as disease activity biomarkers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/768fc8255d7946a49a4243f16da5a926 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF