| Autor: |
Philip Benjamin, Andrew J. Lawrence, Christian Lambert, Bhavini Patel, Ai Wern Chung, Andrew D. MacKinnon, Robin G. Morris, Thomas R. Barrick, Hugh S. Markus |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 4, Iss C, Pp 828-837 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2014.05.009 |
| Popis: |
Objectives: Lacunes are an important disease feature of cerebral small vessel disease (SVD) but their relationship to cognitive impairment is not fully understood. To investigate this we determined (1) the relationship between lacune count and total lacune volume with cognition, (2) the spatial distribution of lacunes and the cognitive impact of lacune location, and (3) the whole brain anatomical covariance associated with these strategically located regions of lacune damage. Methods: One hundred and twenty one patients with symptomatic lacunar stroke and radiological leukoaraiosis were recruited and multimodal MRI and neuropsychological data acquired. Lacunes were mapped semi-automatically and their volume calculated. Lacune location was automatically determined by projection onto atlases, including an atlas which segments the thalamus based on its connectivity to the cortex. Lacune locations were correlated with neuropsychological results. Voxel based morphometry was used to create anatomical covariance maps for these ‘strategic’ regions. Results: Lacune number and lacune volume were positively associated with worse executive function (number p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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