| Autor: |
Anoop Sheshadri, Mason Lai, Fang-Chi Hsu, Scott R. Bauer, Shyh-Huei Chen, Warren Tse, Vasantha Jotwani, Gregory J. Tranah, Jennifer C. Lai, Stein Hallan, Roger A. Fielding, Christine Liu, Joachim H. Ix, Steven G. Coca, Michael G. Shlipak |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Kidney Medicine, Vol 5, Iss 11, Pp 100721- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0595 |
| DOI: |
10.1016/j.xkme.2023.100721 |
| Popis: |
Rationale & Objective: In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could distinguish potential mechanisms for this beneficial effect. Study Design: Randomized controlled trial. Setting & Population: A total of 1,381 sedentary adults aged 70-89 years enrolled in the LIFE trial. Intervention: Structured, 2-year, moderate-intensity exercise intervention versus health education. Outcomes: Physical activity was measured by step count. Primary outcomes were changes in 14 serum and urine biomarkers of kidney health collected at baseline, year 1, and year 2. We determined the effect of randomization on changes in kidney measures and then evaluated observational associations of achieved activity on each measure. Results: Participants assigned to exercise walked on average 291 more steps per day than participants assigned to health education. The intervention was not significantly associated with changes in biomarkers of kidney health. In observational analyses, persons in the highest versus lowest quartile of activity (≥3,470 vs |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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