Yamaguchi esterification: a key step toward the synthesis of natural products and their analogs—a review

Autor:	Ramsha Munir, Ameer Fawad Zahoor, Muhammad Naveed Anjum, Asim Mansha, Ali Irfan, Aijaz Rasool Chaudhry, Ahmad Irfan, Katarzyna Kotwica-Mojzych, Mariola Glowacka, Mariusz Mojzych
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Yamaguchi esterification macrolides terpenoids polyketides peptides metabolites Chemistry QD1-999
Zdroj:	Frontiers in Chemistry, Vol 12 (2024)
Druh dokumentu:	article
ISSN:	2296-2646
DOI:	10.3389/fchem.2024.1477764
Popis:	The Yamaguchi reagent, based on 2,4,6-trichlorobenzoyl chloride (TCBC) and 4-dimethylaminopyridine (DMAP), is an efficient tool for conducting the intermolecular (esterification) reaction between an acid and an alcohol in the presence of a suitable base (Et3N or iPr2NEt) and solvent (THF, DCM, or toluene). The Yamaguchi protocol is renowned for its ability to efficiently produce a diverse array of functionalized esters, promoting high yields, regioselectivity, and easy handling under mild conditions with short reaction times. Here, the recent utilization of the Yamaguchi reagent was reviewed in the synthesis of various natural products such as macrolides, terpenoids, polyketides, peptides, and metabolites.
Databáze:	Directory of Open Access Journals
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