The Mechanism of CD8+ T Cells for Reducing Myofibroblasts Accumulation during Renal Fibrosis

Autor:	Min Gao, Jing Wang, Jianghua Zang, Yina An, Yanjun Dong
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	fibroblast myofibroblast embryonic origin cell diversity development extracellular matrix homeostasis Microbiology QR1-502
Zdroj:	Biomolecules, Vol 11, Iss 7, p 990 (2021)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom11070990
Popis:	Renal fibrosis is a hallmark of chronic kidney disease (CKD) and a common manifestation of end-stage renal disease that is associated with multiple types of renal insults and functional loss of the kidney. Unresolved renal inflammation triggers fibrotic processes by promoting the activation and expansion of extracellular matrix-producing fibroblasts and myofibroblasts. Growing evidence now indicates that diverse T cells and macrophage subpopulations play central roles in the inflammatory microenvironment and fibrotic process. The present review aims to elucidate the role of CD8+ T cells in renal fibrosis, and identify its possible mechanisms in the inflammatory microenvironment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a7676f2d013e417c8214d706f950fce1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.