Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit
| Autor: | Masoud Motalebi Kashani, Mitra Hannani, Mohammad Sabahi-Bidgoli, Alireza Dehdashti, Hamid-Reza Saberi |
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| Jazyk: | perština |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 7, Iss 1, Pp 34-41 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1735-7799 2008-1375 |
| Popis: | Background and Objectives: Oxidative stress due to free radicals formation plays an important role in noise-induced hearing loss (NIHL). Many hypotheses have been proposed regarding the biochemical prevention of this complication. This study was performed with the purpose of determining the preventive effect of N-acetylcysteine (NAC) administration, as an antioxidant agent, on NIHL in Rabbit. Methods: In an experimental study, 24 adult white male rabbits were divided into four groups, including: 1) control, 2) noise exposure (100dB octave band noise centered at 4000Hz for 40h), 3) noise exposure plus NAC administration (325mg/kg, daily ip injection), and 4) no exposure and NAC administration. Audiometric test of rabbits was assessed by auditory brainstem response (ABR) technique in three stages. The Kruskal-Wallis and Mann-Whitney tests were used to compare the groups, and a p |
| Databáze: | Directory of Open Access Journals |
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