Advances of target therapy on NOTCH1 signaling pathway in T-cell acute lymphoblastic leukemia

Autor:	Ruyue Zheng, Menglin Li, Shujuan Wang, Yanfang Liu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	T-cell acute lymphoblastic leukemia NOTCH1 γ-Secretase inhibitors SERCA inhibitors Monoclonal antibody Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-9 (2020)
Druh dokumentu:	article
ISSN:	2162-3619
DOI:	10.1186/s40164-020-00187-x
Popis:	Abstract T-cell acute lymphoblastic leukemia (T-ALL) is one of the hematological malignancies. With the applications of chemotherapy regimens and allogeneic hematopoietic stem cell transplantation, the cure rate of T-ALL has been significantly improved. However, patients with relapsed and refractory T-ALL still lack effective treatment options. Gene mutations play an important role in T-ALL. The NOTCH1 gene mutation is the important one among these genetic mutations. Since the mutation of NOTCH1 gene is considered as a driving oncogene in T-ALL, targeting the NOTCH1 signaling patheway may be an effective option to overcome relapsed and refractory T-ALL. This review mainly summarizes the recent research advances of targeting on NOTCH1 signaling pathway in T-ALL.
Databáze:	Directory of Open Access Journals
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