Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes

Autor: Daniela S. Aliaga Goltsman, Lisa M. Alexander, Jyun-Liang Lin, Rodrigo Fregoso Ocampo, Benjamin Freeman, Rebecca C. Lamothe, Andres Perez Rivas, Morayma M. Temoche-Diaz, Shailaja Chadha, Natalie Nordenfelt, Owen P. Janson, Ian Barr, Audra E. Devoto, Gregory J. Cost, Cristina N. Butterfield, Brian C. Thomas, Christopher T. Brown
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35257-7
Popis: Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. Here, the authors mine an extensive genome-resolved metagenomics database and identified uncharacterized families of RNA-guided, compact nucleases.
Databáze: Directory of Open Access Journals