Investigating the fluctuating nature of post-COVID pain symptoms in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study

Autor: César Fernández-de-las-Peñas, Oscar J. Pellicer-Valero, José D. Martín-Guerrero, Valentín Hernández-Barrera, Lars Arendt-Nielsen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PAIN Reports, Vol 9, Iss 3, p e1153 (2024)
Druh dokumentu: article
ISSN: 2471-2531
00000000
DOI: 10.1097/PR9.0000000000001153
Popis: Abstract. Objective:. This cohort study used Sankey plots and exponential bar plots for visualizing the fluctuating nature and trajectory of post-COVID pain in previously hospitalized COVID-19 survivors. Methods:. A cohort of 1266 subjects hospitalised because of COVID-19 during the first wave of the pandemic were scheduled for a telephone interview at 8.4 (T1), 13.2 (T2), and 18.3 (T3) months in average after hospitalization for collecting data about post-COVID pain. Patients were asked for about pain symptomatology that was attributed to the infection. Hospitalization and clinical data were collected from medical records. Results:. The prevalence of myalgia as COVID-19–associated symptom was 29.82% (n = 389) at hospitalization (T0). The prevalence of post-COVID pain was 41.07% (n = 520) at T1, 34.29% (n = 434) at T2, and 28.47% (n = 360) at T3. The recovery exponential curve revealed a decrease trend visualizing that post-COVID pain improved over the time span investigated. Pain in the lower extremity and widespread pain were the most prevalent locations. Female sex (OR 1.507, 95% CI 1.047–2.169), pre-existing pain symptoms (OR 1.724, 95% CI 1.237–2.403), headache as onset-symptom (OR 2.374, 95% CI 1.550–3.639), days at hospital (OR 1.012, 95% CI 1.000–1.025), and presence of post-COVID pain at T1 (OR 13.243, 95% CI 9.428–18.601) were associated with post-COVID pain at T2. Only the presence of post-COVID pain at T1 (OR 5.383, 95% CI 3.896–7.439) was associated with post-COVID pain at T3. Conclusion:. Current results show a fluctuating evolution with a decreasing tendency of post-COVID pain during the first years after hospitalization. The development of post-COVID pain soon after SARS-CoV-2 infection predispose for long-lasting chronic pain.
Databáze: Directory of Open Access Journals
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