X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever

Autor:	Daniela M Rauseo, Mercedes Fernández-Mestre
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	chikungunya fever toll-like-receptors single-nucleotide polymorphisms disease susceptibility Arctic medicine. Tropical medicine RC955-962
Zdroj:	Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 3, Pp 137-141 (2019)
Druh dokumentu:	article
ISSN:	2352-4146 1995-7645
DOI:	10.4103/1995-7645.254940
Popis:	Objective: To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya Fever. Methods: A total of 177 individuals were studied: 73 patients with a confirmed diagnosis for Chikungunya virus and 104 non-infected individuals. Polymorphisms were determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Our analysis showed an increased CC genotype frequency of the TLR7 rs3853839 polymorphism in male patients compared to control (29% versus 2%, respectively; OR=20.69; 95 % CI= 2.55-167.36; P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7659739789114e899ef0d6ad2d319b9e Zobrazit plný text záznamu View record in DOAJ