Fibrotic Transformation of the Rat Pancreas as Response to the Nitric Oxide Deficiency
| Autor: | B.F. Shevchenko, A.M. Babiy, N.Y. Oshmyanska, V.A. Makarchuk |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Gastroenterologìa, Vol 47, Iss 1.47, Pp 75-79 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2308-2097 2518-7880 |
| DOI: | 10.22141/2308-2097.1.47.2013.86250 |
| Popis: | Non-specific inhibitor of nitric oxide NG-nitro-L-arginine was administrated for the duration of the experiment, and the most significant changes (discirculation and dissecretion) were observed on the 12th day, whereupon the reaction slows due to a compensatory response. On the 30th day of experiment tiny bands of fibrous tissue were formed, which also evidenced by the increase of collagen synthesis markers in blood — protein-bound hydroxyproline (p < 0.05). Incompetence of pancreatic cells was manifested by the reduced activity of pancreatic enzymes (p < 0.05), and the visible hyposecretion of acinar cells on the morphological study. The maximum decrease of nitrite/nitrate concentration was observed after the first day (p < 0.05), with a gradual increase to a maximum on 12th day (p < 0.05). |
| Databáze: | Directory of Open Access Journals |
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