| Autor: |
María San-Román-Gil, Iñigo Martínez-Delfrade, Víctor Albarrán-Fernández, Patricia Guerrero-Serrano, Javier Pozas-Pérez, Jesús Chamorro-Pérez, Diana Rosero-Rodríguez, Pilar Sotoca-Rubio, Ana Maria Barrill-Corpa, Víctor Alia-Navarro, Carlos González-Merino, Coral García-de-Quevedo-Suero, Victoria López, Ignacio Ruz-Caracuel, Cristian Perna-Monroy, Reyes Ferreiro-Monteagudo |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1352262 |
| Popis: |
Immunotherapy has demonstrated a role in the therapeutic landscape of a small subset of patients with colorectal carcinoma (CRC) that harbor a microsatellite instability (MSI-H) status due to a deficient DNA mismatch repair (dMMR) system. The remarkable responses to immune checkpoint inhibitors (ICIs) are now being tested in the neoadjuvant setting in localized CRC, where the dMMR/MSI-H status can be found in up to 15% of patients, with remarkable results obtained in NICHE2 and 3 trials, among others. This case series aims to report our experience at a tertiary center and provide a comprehensive analysis of the possible questions and challenges to overcome if ICIs were established as standard of care in a neoadjuvant setting, as well as the potential role they may have as conversion therapy not only in locoregional advanced CRC but also in oligometastatic disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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