Lithium management of periodic mood fluctuations in behavioural frontotemporal dementia: a case report

Autor: Vicent Llorca-Bofí, Iolanda Batalla, Maria Ruiz-Julián, Marina Adrados-Pérez, Esther Buil-Reiné, Gerard Piñol-Ripoll, Xavier Gallart-Palau, Aurora Torrent
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Psychiatry, Vol 14 (2024)
Druh dokumentu: article
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2023.1325145
Popis: The behavioural variant of Frontotemporal Dementia (bvFTD) is a neurodegenerative condition characterized by behavioural and cognitive symptoms. Mood disturbances, including manic-like episodes, can occur in bvFTD, posing diagnostic and therapeutic challenges. This case report presents a 62-year-old male with bvFTD exhibiting weekly mood fluctuations alternating between manic and depressive-like states. While initial treatment with quetiapine and trazodone showed partial improvement, the periodicity of mood fluctuations persisted. Subsequently, lithium was introduced, resulting in a notable reduction in symptom severity for both manic and depressive episodes. This report highlights the potential use of lithium as a mood stabilizer in bvFTD patients with periodic mood fluctuations, refractory to standard treatments. Further research is needed to elucidate the mechanisms underlying lithium’s efficacy in bvFTD and to establish treatment guidelines.
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