| Autor: |
Joan Marc Cabot, Xavier Subirats, Elisabet Fuguet, Martí Rosés |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
ADMET and DMPK, Vol 2, Iss 2, Pp 98-106 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1848-7718 |
| DOI: |
10.5599/admet.2.2.44 |
| Popis: |
In 1997 Valkó et al. developed a generic fast gradient HPLC method, based on the calculation of the chromatographic hydrophobicity index (CHI) from the gradient retention times, in order to measure lipophilicity. We have enhanced the correlations between CHI and log Po/w and adapted the rapid gradient HPLC method to UHPLC obtaining excellent resolution and repeatability in a short analysis time ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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