| Autor: |
Taewoo Kim, Hyun Bin Cho, Woo Jin Kim, Chang Hyun Lee, Kum Ju Chae, So-Hyun Choi, Kyeong Eun Lee, So Hyeon Bak, Sung Ok Kwon, Gong Yong Jin, Jiwoong Choi, Eun-Kee Park, Ching-Long Lin, Eric A. Hoffman, Sanghun Choi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1465-993X |
| DOI: |
10.1186/s12931-020-01399-9 |
| Popis: |
Abstract Background Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tomography (QCT)-based airway structural and functional metrics due to cement-dust exposure. Methods To reduce confounding factors, subjects with normal spirometry without fibrosis, asthma and pneumonia histories were only selected, and a propensity score matching was applied to match age, sex, height, smoking status, and pack-years. Thus, from a larger data set (N = 609), only 41 cement dust-exposed subjects were compared with 164 non-cement dust-exposed subjects. QCT imaging metrics of airway hydraulic diameter (D h), wall thickness (WT), and bifurcation angle (θ) were extracted at total lung capacity (TLC) and functional residual capacity (FRC), along with their deformation ratios between TLC and FRC. Results In TLC scan, dust-exposed subjects showed a decrease of D h (airway narrowing) especially at lower-lobes (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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