| Autor: |
Wenxiong Xu, Qiumin Luo, Yeqiong Zhang, Chan Xie, Liang Peng |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2024.1427043 |
| Popis: |
Hepatitis B surface antigen (HBsAg) seroclearance is recommended as the ideal endpoint for nucleos(t)ide analog (NA) treatments. Functional cure of chronic hepatitis B (CHB) is defined as having undetectable serum hepatitis B virus (HBV) deoxyribonucleic acid and serum HBsAg. We report a functional cure case of CHB with a family history of hepatocellular carcinoma (HCC) after long-term NA therapy. Despite achieving functional cure for over 7 years, both HBV covalently closed circular deoxyribonucleic acid (cccDNA) and pregenomic ribonucleic acid (pgRNA) remain positive in the liver tissue of the patient, indicating that a sterilizing cure has not been achieved. This case highlights the importance of active surveillance of HBV cccDNA and pgRNA for sterilizing the cure and risk of HCC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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