Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity

Autor: Todorovic Vesna, Prevc Ajda, Zakelj Martina Niksic, Savarin Monika, Bucek Simon, Groselj Blaz, Strojan Primoz, Cemazar Maja, Sersa Gregor
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Radiology and Oncology, Vol 54, Iss 2, Pp 168-179 (2020)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2020-0015
Popis: Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The purpose of this study was to evaluate LDHRS and the effect of PLDR irradiation in isogenic HNSCC cells with different radiosensitivity.
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