| Autor: |
Pantić Igor, Dimitrijević Draga, Stašević-Karličić Ivana, Jeremić Marta, Starčević Ana, Ristić Siniša, Blachnio Agata, Przepiorka Aneta |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Srpski Arhiv za Celokupno Lekarstvo, Vol 147, Iss 11-12, Pp 718-723 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0370-8179 |
| DOI: |
10.2298/SARH181030074P |
| Popis: |
Introduction/Objective. During the past 20 years, there have been numerous attempts to design and apply a simple, affordable blood analysis tool for diagnostic and prognostic purposes in psychiatry. In this article we demonstrate that some mathematical parameters of chromatin organization and distribution in blood neutrophil granulocytes are related to stress levels in patients diagnosed with recurrent depressive disorder (RDD). Methods. The study was performed on 50 RDD participants who were asked to complete Depression, Anxiety and Stress Scales (DASS-21). Peripheral blood samples were obtained from all the participants, smeared on glass slides and stained using a modification of Giemsa method. A total of 500 representative chromatin structures (10 per patient) of neutrophil granulocytes were evaluated using textural analysis with the application of gray level co-occurrence matrix (GLCM) method. Parameters such as angular second moment (indicator of textural uniformity), inverse difference moment (textural homogeneity), and textural sum variance were calculated. Results. The results indicate that there is a statistically highly significant correlation (p < 0.01) between certain chromatin GLCM parameters such as inverse difference moment, and DASS-21 stress score. There was also a significant difference (p < 0.05) in some chromatin GLCM parameters in patients diagnosed with RDD with psychotic features, when compared to the ones without psychosis. Conclusion. These findings suggest that in the future, chromatin GLCM features might have a certain predictive value for some clinical features of recurrent depressive disorder. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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