Enhanced Behavioral Recovery from Sensorimotor Cortex Lesions After Pyramidotomy in Adult Rats

Autor: V. V. Fanardjian, O. V. Gevorkyan, R. K. Mallina, A. B. Melik-Moussian, I. B. Meliksetyan
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Zdroj: Neural Plasticity, Vol 7, Iss 4, Pp 261-277 (2000)
Druh dokumentu: article
ISSN: 2090-5904
1687-5443
DOI: 10.1155/NP.2000.261
Popis: Unilateral transection of the bulbar pyramid, performed before the ablation of the ipsilateral sensorimotor cortex, has been shown to facilitate the recovery of operantly conditioned reflexes and compensatory processes in rats. Such enhanced behaviorai recovery was absent when only the sensorimotor cortex was ablated. This phenomenon is explained by the switching of motor activity under the control of the cortico-rubrospinal system. Switching of the descending influences is accomplished through the following loop: cortico-rubrai projectionred nucleus-inferior olive-cerebellum-thalamuscerebral cortex. This suggests that a preliminary lesion of the peripheral part of the system, represented by a descending spinal projection, facilitates the recovery processes to develop during the subsequent destruction of its central part.
Databáze: Directory of Open Access Journals
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