Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of 'dimethyl dimethoxy biphenyl dicarboxylate' in male Wistar rats

Autor:	Heba M. I. Abdallah, Gihan F Asaad, Mahmoud S Arbid, Yousra A Nomier
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	analgesic antipyretic antihyperlipidemic anti-inflammatory dimethyl dimethoxy biphenyl dicarboxylate triton x-100 Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Zdroj:	Journal of Advanced Pharmaceutical Technology & Research, Vol 13, Iss 2, Pp 83-88 (2022)
Druh dokumentu:	article
ISSN:	2231-4040 0976-2094
DOI:	10.4103/japtr.japtr_292_21
Popis:	Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.
Databáze:	Directory of Open Access Journals
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