Plasma 25-Hydroxyvitamin-D (25-OHD) levels and late-stage age-related macular degeneration (AMD): Assessing the correlation

Autor: Supanji Supanji, Dewi Fathin Romdhoniyyah, Ayudha Bahana Ilham Perdamaian, Anindita Dianratri, Muhammad Bayu Sasongko, Angela Nurini Agni, Tri Wahyu Widayanti, Firman Setya Wardhana, Dian Caturini Sulistyaningrum, Mohammad Eko Prayogo, Masashi Kawaichi, Chio Oka
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), Pp 235-242 (2022)
Druh dokumentu: article
ISSN: 2085-4145
2527-2950
DOI: 10.20885/JKKI.Vol13.Iss3.art3
Popis: Background: Age-related Macular Degeneration (AMD) is a degenerative disease caused by multiple factors, including inflammation. This condition may lead to irreversible macular damage. Vitamin D has anti-inflammatory and immune-modulating qualities, therefore, is expected to protect against the development of AMD. Objective: This study aimed to evaluate the correlation between plasma 25-hydroxyvitamin D (plasma 25-OHD) levels and neovascular Age-Related Macular Degeneration (nAMD). Methods: This was a case-control study involving AMD and control subjects. All subjects underwent a standardized eye examination to check for eligibility by a retinal specialist. Blood samples were drawn for analysis using a DRG Elisa Kit to determine the plasma 25-OHD (Total). Plasma 25-OHD levels were categorized into deficiency (50 ng/mL). Results: Total subjects were 39, which consisted of 20 AMD subjects and 19 controls. There were 17 male subjects (43.6%) and 22 female subjects (56.4%). The mean age for the case and control group was 69.35±7.04 and 68.26±6.83, respectively (p=0.612). Those in their 70s dominated the age distribution with a percentage of 56.41% of all participants. The mean plasma 25-OHD in the case group was 32.30±17.10 ng/mL, while the control group was 50.63±11.95 ng/mL (p=0.066). There was no significant association between AMD and plasma 25-OHD levels in all groups (p>0.05). Conclusion: Plasma 25-OHD levels did not correlate positively with nAMD in our study population.
Databáze: Directory of Open Access Journals
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