A prospective comparison of adaptive and fixed boost plans in radiotherapy for glioblastoma

Autor: Tomohiko Matsuyama, Yoshiyuki Fukugawa, Junichiro Kuroda, Ryo Toya, Takahiro Watakabe, Tadashi Matsumoto, Natsuo Oya
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Radiation Oncology, Vol 17, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1748-717X
DOI: 10.1186/s13014-022-02007-4
Popis: Abstract Purpose To analyze the efficacy of adaptive radiotherapy (ART) for glioblastoma. Methods Sixty-one glioblastoma patients who received ART were prospectively evaluated. The initial clinical target volume (CTVinitial) was represented by T2 hyperintensity on postoperative MRIs (pre-RT MRI [MRIpre])plus 10 mm. The initial planning target volume (PTVinitial) was the CTVinitial plus a 5-mm margin. The PTVinitial received 40 Gy. An MRI and a second planning CT were performed during radiotherapy (MRImid). Two types of boost CTVs (the resection cavity and residual tumor on enhanced T1-weighted MRI plus 10 mm) were created based on the MRIpre and MRImid (CTVboost-pre and -mid). The boost PTV (PTVboost) was the CTVboost plus 5 mm. Two types of boost plans (fixed and adaptive boost plans in the first and second planning CT, respectively) of 20 Gy were created. The PTV based on the post-RT MRI (PTVboost-post) was created, and the dose-volume histograms of the PTVboost-post in the fixed and adaptive boost plans were compared. Additionally, the conformity indices (CIs) of the fixed and adaptive boost plans were compared. Results The median V95 of the PTVboost-post of the fixed and adaptive boost plans (V95pre and V95mid) were 95.6% and 98.3%, respectively (P
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