Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia.

Autor: Sètondji Cocou Modeste Alexandre Yahouédéhou, Caroline Conceição da Guarda, Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Suellen Pinheiro Carvalho, Luciana Magalhães Fiuza, Uche Samuel Ndidi, Rodrigo Mota Oliveira, Magda Oliveira Seixas Carvalho, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha, Isa Menezes Lyra, Elisângela Vitória Adorno, Marilda Souza Goncalves
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: PLoS ONE, Vol 14, Iss 7, p e0218040 (2019)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0218040
Popis: This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p
Databáze: Directory of Open Access Journals
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