Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics

Autor:	Carlos F. G. C. Geraldes
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	contrast agents functionalized nanoparticles manganese oxides magnetic resonance imaging multimodal imaging theranostics Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 23, p 5591 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29235591
Popis:	Manganese-based MRI contrast agents have recently attracted much attention as an alternative to Gd-based compounds. Various nanostructures have been proposed for potential applications in in vivo diagnostics and theranostics. This review is focused on the discussion of different types of Mn oxide-based nanoparticles (MnxOy NPs) obtained at the +2, +3 and +4 oxidation states for MRI, multimodal imaging or theranostic applications. These NPs show favorable magnetic properties, good biocompatibility, and an improved toxicity profile relative to Gd(III)-based nanosystems, showing that the Mn paramagnetic ions offer advantages for the next generation of nanoscale MRI and theranostic contrast agents. Their potential for enhancing relaxivity and MRI contrast effects is illustrated through discussion of selected examples published in the past decade.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/75bf9f1d038448149a4bf3c85f98e894 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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