Progressive supranuclear palsy: new concepts
| Autor: | Orlando Graziani Povoas Barsottini, André Carvalho Felício, Camila Catherine Henriques de Aquino, José Luiz Pedroso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 68, Iss 6, Pp 938-946 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282X |
| DOI: | 10.1590/S0004-282X2010000600020 |
| Popis: | Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|