Effects of Dextromethorphan on Depressive- and Cognitive-Associated Behaviors: A Sexually Dimorphic Study

Autor:	Omamuyovwi Meashack Ijomone, Ifechukwude Joachim Biose
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	dextromethorphan depression cognition hippocampus female male Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Basic and Clinical Neuroscience, Vol 10, Iss 4, Pp 393-400 (2019)
Druh dokumentu:	article
ISSN:	2008-126X 2228-7442
Popis:	Introduction: We investigated the sexually dimorphic effects of Dextromethorphan (DM) on cognitive and depression-like behaviors as well as on hippocampal histology in rats following acute administration. Methods: Wistar rats of both sexes were treated with 25 or 50 mg/kg of DM for 7 days via intraperitoneal injection. At the end of the administration, behavioral studies were performed on the Tail Suspension Test (TST) for depressive-like behaviors and the Y-maze for cognitive behaviors. The rats’ brains were excised and processed for routine histological analysis. Results: Our results showed that DM significantly increased (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/75b3d57150da431bad9ed949ab619955 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF