An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide

Autor:	Micaela Giannetti, Viviana Claudia Canale, Laura Micheli, Maurizio Fiori, Claudia Mazzuca, Antonio Palleschi
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Furosemide aging photo-chemistry 4-chloro-5-sulfamoylanthranilyc acid furfuryl alcohol Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 1, p 381 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28010381
Popis:	Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact from a health and marketing point of view. Many studies have tried to explain this phenomenon under different experimental conditions, but no detailed explanation of the yellowing phenomenon has been provided. This work, unlike the others, provides an overall view and explanation of the behavior of FUR in relation to the yellowing phenomenon, both in the solution and in solid state, considering several aspects, such as light exposure, presence of oxygen, and moisture effects.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/75ac54e9276745b68077f6da092400fb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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