Autor: |
Xiaorui Liu, Chunmei Chen, Yinyu Zheng, Mi Zhang, Qingyi Tong, Junjun Liu, Qun Zhou, Jianping Wang, Zengwei Luo, Hucheng Zhu, Yonghui Zhang |
Jazyk: |
angličtina |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Frontiers in Chemistry, Vol 6 (2018) |
Druh dokumentu: |
article |
ISSN: |
2296-2646 |
DOI: |
10.3389/fchem.2018.00605 |
Popis: |
(±)-Peniorthoesters A and B (±1 and ±2), two pairs of unprecedented spiro-orthoester enantiomers with a 1,4,6-trioxaspiro[4. 5]decane-7-one unit, were obtained from Penicillium minioluteum. Their structures were determined by spectroscopic methods, X-ray diffraction analyses, and ECD calculations. (±)-Peniorthoesters A and B are the first examples of spiro-orthoester enantiomers, and they represent the first spiro-orthoesters originating from fungi. All compounds showed potential inhibitory activities comparable to dexamethasone against NO production with IC50 values ranging from 14.2 to 34.5 μM. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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