Severe postpartum hemorrhage and the risk of adverse maternal outcome: A comparative analysis of two population-based studies in France and the Netherlands

Autor: P.L.M. de Vries, C. Deneux-Tharaux, C. Caram-Deelder, F. Goffinet, D.D.C.A. Henriquez, A. Seco, J.G. van der Bom, T. van den Akker
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Preventive Medicine Reports, Vol 40, Iss , Pp 102665- (2024)
Druh dokumentu: article
ISSN: 2211-3355
DOI: 10.1016/j.pmedr.2024.102665
Popis: Objectives: Among women with severe PPH (sPPH) in France and the Netherlands, we compared incidence of adverse maternal outcome (major obstetric hemorrhage (≥2.5L blood loss) and/or hysterectomy and/or mortality) by mode of delivery. Second, we compared use and timing of resuscitation and transfusion management, second-line uterotonics and uterine-sparing interventions (intra-uterine tamponade, compression sutures, vascular ligation, arterial embolization) by mode of delivery. Methods: Secondary analysis of two population-based studies of women with sPPH in France and the Netherlands. Women were selected by a harmonized definition for sPPH: (total blood loss ≥ 1500 ml) AND (blood transfusion of ≥ 4 units packed red blood cells and/or multicomponent blood transfusion). Findings: Incidence of adverse maternal outcome after vaginal birth was 793/1002, 9.1 % in the Netherlands versus 88/214, 41.1 % in France and 259/342, 76.2% versus 160/270, 59.3% after cesarean. Hemostatic agents such as fibrinogen were administered less frequently (p
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