The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner

Autor: Subramanya Srikantan, Yilun Deng, Zi-Ming Cheng, Anqi Luo, Yuejuan Qin, Qing Gao, Glaiza-Mae Sande-Docor, Sifan Tao, Xingyu Zhang, Nathan Harper, Chris E. Shannon, Marcel Fourcaudot, Zhi Li, Balakuntalam S. Kasinath, Stephen Harrison, Sunil Ahuja, Robert L. Reddick, Lily Q. Dong, Muhammad Abdul-Ghani, Luke Norton, Ricardo C. T. Aguiar, Patricia L. M. Dahia
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-12661-0
Popis: TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity.
Databáze: Directory of Open Access Journals